San Luis Obispo (SLO) County wine is a appellation that designates wine made from grapes grown in San Luis Obispo (SLO) County, California which is sandwiched between Santa Barbara County to the south and Monterey County at the northern boundary on the Pacific coast. Its location sits halfway between the cities of San Francisco and Los Angeles on the north–south axis of U.S. Route 101 and Pacific Coast Highway (PCH). The county lies entirely within the Central Coast viticultural area. County names in the United States automatically qualify as legal appellations of origin for wine produced from grapes grown in that county and do not require registration with the Alcohol and Tobacco Tax and Trade Bureau (TTB) of the Treasury Department. TTB was created in January of 2003, when the Bureau of Alcohol, Tobacco and Firearms, or ATF, was extensively reorganized under the provisions of the Homeland Security Act of 2002.

Central Coast is a vast American Viticultural Area (AVA) that spans along the Central California Pacific coastline from the San Francisco Bay Area south through Monterey, San Luis Obispo and Santa Barbara Counties. It was established on November 25, 1985 by the Bureau of Alcohol, Tobacco and Firearms (ATF), Treasury after reviewing the petition submitted by Taylor California Cellars, a winery in Gonzales, California, to establish the "Central Coast" viticultural area. The boundaries of the Central Coast, which have been expanded twice, includes portions of six counties where approximately 100,000 acres (40,469 ha) cultivated with Chardonnay being more than half of the varietal. Within the multi-county AVA are numerous established appellations that share the same maritime climate produced by the Pacific Ocean.