San Luis Obispo High School, also referred to as "San Luis High" and "SLO High", is an American public high school in San Luis Obispo, California. It is the only non-continuation public high school within the city. The school is within the San Luis Coastal Unified School District (SLCUSD), serving primarily students living in San Luis Obispo. Before the school's addition of ninth grade in 1982, the school was known as "San Luis Obispo Senior High School" (SLOSH). School colors are black and gold.

San Luis Obispo is a city and county seat of San Luis Obispo County, in the U.S. state of California. Located on the Central Coast of California, San Luis Obispo is roughly halfway between the San Francisco Bay Area in the north and Greater Los Angeles in the south. The population was 47,063 at the 2020 census.