San Marcos is a department in northwestern Guatemala, on the Pacific Ocean and along the western Guatemala-Mexico border.

In a protracted conflict during the Spanish colonization of the Americas, Spanish colonisers gradually incorporated the territory that became the modern country of Guatemala into the colonial Viceroyalty of New Spain. Before the conquest, this territory contained a number of competing Mesoamerican kingdoms, the majority of which were Maya. Many conquistadors viewed the Maya as "infidels" who needed to be forcefully converted and pacified, disregarding the achievements of their civilization. The first contact between the Maya and European explorers came in the early 16th century when a Spanish ship sailing from Panama to Santo Domingo was wrecked on the east coast of the Yucatán Peninsula in 1511. Several Spanish expeditions followed in 1517 and 1519, making landfall on various parts of the Yucatán coast. The Spanish conquest of the Maya was a prolonged affair; the Maya kingdoms resisted integration into the Spanish Empire with such tenacity that their defeat took almost two centuries.