San Margherita is an unincorporated neighborhood directly west of Columbus, Ohio, half falling into Norwich Township and the other half in Franklin Township. The area was settled in the early 20th century by Italian immigrants working for the Marble Cliff Quarry Company. Though once a robust and rural community, San Margherita is in danger of vanishing. Many of the original homes and locally owned businesses in the neighborhood have been demolished.

The Marble Cliff Quarry Co., is located in the community of San Margherita and operated the largest limestone quarry in the United States from its founding in 1913 until its sale in 1985.