San Miguel Ixtahuacán is a municipality in the San Marcos department of Guatemala. It comprises 19 villages, and the population is about 39,000 people. The majority of people are ethnically Maya- Mam and speak the Mam and Spanish languages. Most inhabitants subsist by farming, growing crops of corn, beans, vegetables and fruits, irrigated from the Cuilco River and its tributaries.

San Marcos is a department in northwestern Guatemala, on the Pacific Ocean and along the western Guatemala-Mexico border.