San Sebastiano al Palatino is a church on the northeastern corner of the Palatine Hill in Rome. It is dedicated to Saint Sebastian, a late-third-century Christian martyr under the reign of Diocletian. According to legend, the church was built on the site of the saint's "first" martyrdom with arrows, which was unsuccessful.

There are more than 900 churches in Rome, which makes it the city with the largest number of churches in the world. Almost all of these are Catholic.