Sanderson station is an Amtrak railway station serving the small West Texas town of Sanderson. The unstaffed station is located alongside West Downie Street in the southwest corner of the town. The station accommodates travelers who use the combined Sunset Limited and Texas Eagle, operating between Los Angeles and New Orleans or Chicago, respectively.

Sanderson is a census-designated place (CDP) in and the county seat of Terrell County, Texas, United States. The population was 837 at the 2010 census. Sanderson was created in 1882 as a part of neighboring Pecos County. It became the seat of Terrell County in 1905.