Sandford Lock is a lock on the River Thames in England, situated at Sandford-on-Thames which is just south of Oxford. The first pound lock was built in 1631 by the Oxford-Burcot Commission although this has since been rebuilt. The lock has the deepest fall of all locks on the Thames at 8 ft 9in (2.69m) and is connected to a large island which is one of three at this point. The lock lies at the end of Church Lane in Sandford on Thames.

Sandford-on-Thames, also referred to as simply Sandford, is a village and Parish Council beside the River Thames in Oxfordshire just south of Oxford. The village is just west of the A4074 road between Oxford and Henley.