The Sandy Creek Expedition, also known as the Sandy Expedition or the Big Sandy Expedition, was a 1756 campaign by Virginia Regiment soldiers and Cherokee warriors into modern-day West Virginia against the Shawnee, who were raiding the British colony of Virginia's frontier. The campaign set out in mid-February, 1756, and was immediately slowed by harsh weather and inadequate provisions. With morale failing, the expedition was forced to turn back in mid-March without encountering the enemy.

Lower Shawneetown, also known as Shannoah or Sonnontio, was an 18th-century Shawnee village located within the Lower Shawneetown Archeological District, near South Portsmouth in Greenup County, Kentucky and Lewis County, Kentucky. The population eventually occupied areas on both sides of the Ohio River, and along both sides of the Scioto River in what is now Scioto County, Ohio. It was added to the National Register of Historic Places on 28 April 1983. It is near the Bentley site, a Madisonville Horizon settlement inhabited between 1400 CE and 1625 CE. Nearby, to the east, there are also four groups of Hopewell tradition mounds, built between 100 BCE and 500 CE, known as the Portsmouth Earthworks.