The House of Sanguszko is a Polish and Lithuanian noble and aristocratic family of Lithuanian and Ruthenian origin, connected to the Gediminid dynasty. Like other princely houses of Polish–Lithuanian Commonwealth, its origins are considered murky. Present historical opinion holds in favour of their descent from Algirdas' grandson Alexander, lord of Kovel and Liuboml, whose name can be shortened to Sangush. The family supposedly descends from two lines, associated with two of his sons, Alexander and Michael.

The House of Gediminid or simply the Gediminids were a dynasty of monarchs in the Grand Duchy of Lithuania that reigned from the 14th to the 16th century. A cadet branch of this family, known as the Jagiellonian dynasty, reigned also in the Kingdom of Poland, Kingdom of Hungary and Kingdom of Bohemia. Several other branches ranked among the leading aristocratic dynasties of Russia and Poland into recent times.