Sansepolcro, formerly Borgo Santo Sepolcro, is a town and comune founded in the 11th century, located in the Italian Province of Arezzo in the eastern part of the region of Tuscany.

The province of Arezzo is a province in the Tuscany region of Italy. Its capital is the city of Arezzo. The province is bordered by the regions of Marche, Emilia-Romagna, Umbria, and the provinces Siena and Florence of Tuscany. It has an area of 3,233 square kilometres (1,248 sq mi), a total population of about 344,000 in 36 comuni.