The Santa Ana Zoo at Prentice Park in Santa Ana, California, is a 20-acre (8.1 ha) zoo focusing on the animals and plants of Central and South America. The Santa Ana Zoo hosts more than 270,000 people annually. The zoo opened in 1952 and is owned and operated by the City of Santa Ana. Joseph Prentice donated land for the zoo with the stipulation that the city must keep at least 50 monkeys at all times. The zoo maintains an extensive primate collection with over a dozen species from around the world.

Santa Ana is a city in and the county seat of Orange County, California, United States. Located in the Greater Los Angeles region of Southern California, the city's population was 310,227 at the 2020 census, making Santa Ana the second most populous city in Orange County, the 13th-most populous city in California, and the 64th densest large city in the United States. Santa Ana is a major regional economic and cultural hub for the Orange Coast.