Santa Bárbara Airlines Flight 518 was an ATR 42–300 twin-turboprop aircraft, registration YV1449, operating as a scheduled domestic flight from Mérida, Venezuela, to Caracas that crashed into the side of a mountain on 21 February 2008, shortly after take-off. There were 43 passengers on board, with a crew consisting of two pilots and a flight attendant. The wreckage was discovered a day later with no survivors. It was the deadliest aviation accident involving an ATR 42 until Trigana Air Flight 267 crashed in Papua, Indonesia, in 2015 with 54 deaths.

The ATR 42 is a regional airliner produced by Franco-Italian manufacturer ATR, with final assembly in Toulouse, France. On 4 November 1981, the aircraft was launched with ATR, as a joint venture between French Aérospatiale and Aeritalia . The ATR 42-300 performed its maiden flight on 16 August 1984 and type certification was granted during September 1985. Launch customer Air Littoral operated its first revenue-earning flight in December of that year.