Santa Clara is a town in Franklin County, New York, United States. The population was 345 at the 2010 census. The name was derived from the wife of an early town businessman, John Hurd.

Franklin County is a county on the northern border of the U.S. state of New York. To the north across the Canada–United States border are the Canadian provinces of Quebec and Ontario, from east to west. As of the 2020 census, the county population was 47,555. Its county seat is Malone. The county is named in honor of United States Founding Father Benjamin Franklin. The county is part of the North Country region of the state.