Santa Cruz River is a river in the Argentine province of Santa Cruz. The Santa Cruz begins at the shore of the Viedma and Argentino Lakes, of glacial origin and located in the Los Glaciares National Park, and runs 385 kilometres (239 mi) eastwards before reaching the Atlantic Coast, 350 kilometres (217 mi) north of the southern tip of South America, creating a delta. It is one of the last large free-flowing rivers in Patagonia.

Santa Cruz Province is a province of Argentina, located in the southern part of the country, in Patagonia. It borders Chubut Province to the north, and Chile to the west and south, with an Atlantic coast on its east. Santa Cruz is the second-largest province of the country, and the least densely populated in mainland Argentina.