Santa Cruz de la Palma is a city and a municipality on the east coast of the island of La Palma in the province of Santa Cruz de Tenerife of the Canary Islands. Santa Cruz de la Palma is the second-largest city and is the capital of the island. It is along an old lava flow coming from the Caldereta, a volcano just south of the city.

La Palma, also known as La isla bonita and historically San Miguel de La Palma, is the most northwesterly island of the Canary Islands, Spain, which is a Spanish autonomous community and archipelago in Macaronesia in the North Atlantic Ocean. La Palma has an area of 708.32 square kilometres (273.48 sq mi) making it the fifth largest of the eight main Canary Islands. The total population at the start of 2023 was 84,338, of which 15,522 lived in the capital, Santa Cruz de La Palma and 20,375 in Los Llanos de Aridane. Its highest mountain is the Roque de los Muchachos, at 2,426 metres (7,959 ft), being second among the peaks of the Canaries after the Teide massif on Tenerife.