Mompox or Mompós, officially Santa Cruz de Mompox, is a town and municipality in northern Colombia, in the Bolívar Department. The town initially grew from its proximity to the Magdalena river and has preserved much of its colonial character. It also played an important role in the liberation of South America from Spain. Today, Mompox depends upon tourism, fishing, and some commerce generated by the local cattle raising. The municipality has a population of 46,408 and is adjacent to the municipalities of Pinillos and San Fernando. The historic center of Mompox was made a UNESCO World Heritage Site in 1995, owing to its preserved colonial architecture and mixture of architectural styles.

The Magdalena River is the main river of Colombia, flowing northward about 1,528 kilometres (949 mi) through the western half of the country. It takes its name from the biblical figure Mary Magdalene. It is navigable through much of its lower reaches, in spite of the shifting sand bars at the mouth of its delta, as far as Honda, at the downstream base of its rapids. It flows through the Magdalena River Valley.