Santa Fe is a district (distrito) of Veraguas Province in Panama. The population according to the 2000 census was 12,890; the latest official estimate is 17,341. The district, which lies in the north of the province and comprises its entire Caribbean coastal area, covers a total area of 1,920 km². The capital lies at the town of Santa Fe.

Veraguas is a province of Panama, located in the centre-west of the country. The capital is the city of Santiago de Veraguas. It is the only Panamanian province to border both the Atlantic and Pacific oceans. It covers an area of 10,587.6 km² and in 2023 it had a population of 259,791.