The Santa Isabel College, also referred to by its acronym SIC, is a private, Roman Catholic college owned and operated by the Sisters of Charity of Saint Vincent De Paul in Ermita, Manila, Philippines. It was founded on 24 October 1632. Santa Isabel College is one of the oldest colleges in the Philippines and in Asia.

Ermita is a district in Manila, Philippines. Located at the central part of the city, the district is a significant center of finance, education, culture, and commerce. Ermita serves as the civic center of the city, bearing the seat of city government and a large portion of the area's employment, business, and entertainment activities.