La Santa María de la Inmaculada Concepción, or La Santa María, originally La Gallega, was the largest of the three small ships used by Christopher Columbus in his first expedition across the Atlantic Ocean in 1492, with the backing of the Spanish monarchs. Her master and owner was Juan de la Cosa.

Christopher Columbus was an Italian explorer and navigator from the Republic of Genoa who completed four Spanish-based voyages across the Atlantic Ocean sponsored by the Catholic Monarchs, opening the way for the widespread European exploration and European colonization of the Americas. His expeditions were the first known European contact with the Caribbean and Central and South America.