Santa María de Guía de Gran Canaria is a town and a municipality in Las Palmas province of the Canary Islands. It is located on the north side of Gran Canaria island. Its population is 13,811 (2013), and the area is 42.59 km2 (16.44 sq mi).

Gran Canaria, also Grand Canary Island, is the third-largest and second-most-populous island of the Canary Islands, an archipelago off the Atlantic coast of Northwest Africa and is part of Spain. As of 2023 the island had a population of 862,893 that constitutes approximately 40% of the population of the archipelago. Las Palmas de Gran Canaria, the capital of the island, is the biggest city of the Canary Islands and the ninth of Spain.