Santa María del Oro is a town and municipality, in the Southeastern Region of Jalisco, in central-western Mexico. The municipality covers an area of 776.4 km2.

Jalisco is a state in Western Mexico that is divided into 125 municipalities. According to the 2020 Mexican census, it is the third most populated state with 8,348,151 inhabitants and the seventh largest by land area spanning 78,595.9 square kilometres (30,346.0 sq mi). The largest municipality by population is Zapopan, with 1,476,491 residents, while the smallest is Santa María del Oro with 1,815 residents. The largest municipality by land area is Mezquitic which spans 3,363.60 km2 (1,298.69 sq mi), and the smallest is Techaluta with 79.20 km2 (30.58 sq mi). The newest is San Ignacio Cerro Gordo, established in 2007 out of Arandas.