Santa Margherita di Belice is a town in the Province of Agrigento in the Italian region of Sicily. It lies in southwest Sicily, 400 metres (1,300 ft) above sea level, near where the borders of the Province of Agrigento, Province of Trapani and Province of Palermo meet. It is approximately 60 kilometres (37 mi) southwest of the city of Palermo, 60 kilometres (37 mi) northwest of the city of Agrigento and sits in the Belice valley among the rivers Belice, Senore and Carboj.

The province of Agrigento is a province in the autonomous island region of Sicily, Italy, situated on its south-western coast. Following the suppression of the Sicilian provinces, it was replaced in 2015 by the free municipal consortium of Agrigento. It has an area of 3,041.90 square kilometres (1,174.48 sq mi), and a total population of 474,493. There are 43 comuni in the province.