Santa Maria in Palmis, also known as Chiesa del Domine Quo Vadis, is a small church southeast of Rome. It is located about some 800 m from Porta San Sebastiano, where the Via Ardeatina branches off the Appian Way, on the site where, according to the apocryphal Acts of Peter, Saint Peter met the risen Christ while Peter was fleeing persecution in Rome. According to the tradition, Peter asked him, "Lord, where are you going?". Christ answered, "I am going to Rome to be crucified again".

The Appian Way is one of the earliest and strategically most important Roman roads of the ancient republic. It connected Rome to Brindisi, in southeast Italy. Its importance is indicated by its common name, recorded by Statius, of Appia longarum... regina viarum . The road is named after Appius Claudius Caecus, the Roman censor who, during the Samnite Wars, began and completed the first section as a military road to the south in 312 BC.