Santa Mesa station is a railway station located on the South Main Line in the city of Manila, Philippines. It is one of two stations in the line to have its own access road.

The PNR Metro Commuter Line was a commuter rail line operated by the Philippine National Railways. It was first inaugurated as the Metro Manila Commuter Service in 1970, and originally served the North Main Line and the South Main Lines, as well as the defunct Carmona and Guadalupe branch lines. Since then, it adopted several names such as Metrotrak and Metrotren, before adopting its present name in the late 2000s. The line was also nicknamed the Orange Line due to its designation in the 1970s.