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Santander, Spain

Santander is the capital of the autonomous community and historical region of Cantabria situated on the north coast of Spain. It is a port city located east of Gijón and west of Bilbao with a population of 172,000, it is believed to have been a port since ancient times, due to its favorable location, is documented as far back as the 11th century. Much of the medieval city was lost in the Great Fire of 1941. Today, its remaining old town and other attractions are popular with tourists and other visitors and its economy is service based; the port is still active and a regular ferry service operates to the United Kingdom. Fish and seafood dominate the local cuisine. Santander notably houses the headquarters of multinational bank Banco Santander, founded there; the origin of the earliest human settlements in the current Santander is not easy to establish because there is little written and archaeological data. However, there would appear to be good practical reasons for ancient settlers to have chosen the north side of the bay, sheltered from it and safer from the storms of the Bay of Biscay, on the north side of the promontory of Somorrostro and along the ancient Becedo estuary.

Moreover, the hillside provided good visibility for spotting potential attackers, making this the ideal place for the foundation of a stable settlement, to evolve throughout the Middle Ages. Although it is mentioned for the first time in 1068, in a draft document made by King Sancho II, in the 9th century Alfonso II the Chaste founded the Abbey of the Holy Bodies in the existing chapel on the hill of Somorrostro, housing as holy relics the heads of Saint Emeterius and Saint Celedonius and the graves of other unknown martyrs, giving the abbey its name. During the 12th and 13th centuries the population was contained within the walls of two different pueblas. La Puebla, the older, on the hill overlooking the city facing the bay, included the old castle, the Abbey of the Holy Bodies and the cloister, it had three rows of houses, separated by Rua Carnicerias and Rua Mayor, where the homes of prominent people of the town were, as well as those of the Abbot's canons. Meanwhile, the Puebla Nueva contained the convent of Santa Clara and San Francisco, which gave its name to one of the main streets.

The two pueblas were joined by a bridge over the river that divided Becedo and flowed down to the shipyards, which were ordered by the king to take timber from the Cantabrian forests for shipbuilding. The villa was required to give the monarchy a ship per year; the city owes its existence to the excellent harbour of the Bay of Santander. Santander was an important port for Castile in the Middle Ages, for trade with the New World, it became a city in 1755. Main article: Great Fire of 1941. Santander fell victim to a great fire in 1941. Fanned by a strong south wind, the fire burned for two days; the fire started in Cádiz Street, next to the Cathedral and the medieval quarter. The fire destroyed the Old Town Hall, Jesús de Monasterio and Vargas streets and Atarazanas square buildings, it led to a major change in the architecture of Santander, away from the older small stone and wood buildings with balconies to the enormous blocks of flats built during the reconstruction. There was only one casualty of the fire, a firefighter from Madrid killed in the line of duty, but thousands of families were left homeless and the city was plunged into chaos.

The fire destroyed the greater part of the medieval town centre and gutted the city's Romanesque cathedral. The city is located on the northern side of the Bahia de Santander; the city of Santander has an oceanic climate, the annual thermal oscillation of the average monthly temperatures reaching around 10 °C. The maximum temperature reached in Santander Airport was 37.8 °C on 27 June 2009, the minimum temperature −5.4 °C on 21 January 1957. The warmest maximum daytime average for a month was in August 2003, with 27.1 °C. Warm months are however rare. Sunshine hours are low by comparison with the rest of mainland and southern Spain. Compared with other areas of northern Spain, such as Galicia, which have much more sunshine hours in coastal cities such as Vigo or Pontevedra. With just around 1650 hours of sunshine, Santander is about as sunny as London and Paris, quite a bit less sunny than most of England's south coastal regions; the bars and restaurants of the old town are popular with tourists, as well as the El Sardinero beach a couple of kilometres away.

The Cathedral of Santander: The lower temple, called "cripta del Cristo" was built around 1200 on other earlier Roman buildings. It is 18 wide, organised into three naves, its style is a transition from romanesque to gothic. The Lighthouse of Cabo Mayor presides over the entrance to the Bay of Santander. Parque de la Vaguada de las Llamas is one of the largest parks in northern Spain, covering 11 hectares of the city. Santander is pilot for a Smart city, it is embedded with 12,000 sensors. The People's Party were the leading party in the municipal elections of 1999, 2003 and 2007; as a service centre at the regional level, Santander contains important public institutions and private organisations with a large number of employees, including Marqués de Valdecilla University Hospital, the University of Cantabria and Grupo Santander. Activities related to culture and tourism are an important part of the city's economy, the regional and municipal authorities look to augment the summer tourist trade with additional offerings, including conventions, cultural festiva

Hochschule für Musik, Theater und Medien Hannover

Hochschule für Musik, Theater und Medien Hannover is an artistic-scientific university in Hanover, Lower Saxony, Germany. It dates back to 1897. From 1962 until 2010 it was named Hochschule für Musik und Theater Hannover, short: Musikhochschule Hannover. Since 2010, the president is Susanne Rode-Breymann; as of 2013, the university has 1,443 students, taught by 361 teachers in 33 courses for musicians, music teachers and media scholars. The university traces its history back to 1897, when a private "Conservatorium für Musik" began its operation, it was made the Konservatorium of the city in 1911. In 1943 the institution was named Landesmusikschule; the building was destroyed. In 1950, the Landesmusikschule was united with a private "Hannoversche Schauspielschule" to form the Akademie für Musik und Theater. In 1958 the school achieved the status of Hochschule and was organized as "Niedersächsische Hochschule für Musik und Theater" and "Niedersächsische Musikschule Hannover". In 1962 the two were united as the "Staatliche Hochschule für Musik und Theater".

Between 1970 and 1973 the present main building was built at the Emmichplatz, bordering the park Eilenriede. In 1973 the state Lower Saxony is responsible for the organisation of the Hochschule. In 1978 it received the status of an artistic-scientific university; the European Centre for Jewish Music was established by Andor Izsák in the Villa Seligmann in 1988, which since 1992 has been an institute of HMTH. It deals with the reconstruction of Jewish liturgical music. Since 2001 the university runs an institute for the early training of gifted students, the'Institut zur Früh-Förderung Hochbegabter'. In 2010 the'Institute of Chamber Music' and the'Institute for Early Music' was founded; the name was extended by "Media". The main building of the university is a structure in the shape of an ear, reflected in the logo, it was one of the most modern buildings designed for the purpose of an artistic institution. In addition to the main site at the Emmichplatz, it has sites at Schiffgraben, Bismarckstraße and the Expo Plaza, the site of the Expo 2000.

The Villa Seligmann the home of director of Continental AG in the Hohenzollernstraße, was acquired in 2006 for the European Centre for Jewish Music and opened in 2012 after restoration. The HMTMH offers all of the standard classical courses of a university of music; the emphasis is on the areas of music education, artistic education, solo training, theatre training. It teaches jazz, pop as part of a popular music program, with an emphasis on jazz; the study programs in the areas of piano and chamber music are pronounced in the artistic education and music education. The drama and opera departments are in close cooperation with the Staatsoper Hannover, the Staatstheater Hannover and the NDR Radiophilharmonie; the university stages about two annual opera productions, including premieres, about three orchestral concerts. The university maintains artistic and scientific relations with several national and international music colleges and universities, including Switzerland, Eastern Europe and East Asia.

The HMTMH owns. Called the Spanish organ, it was installed on the north balcony 1998–2001 by Patrick Collon, it reflects principles of Spanish Baroque organ building without copying a specific instrument. The university has had the following presidents: 1979-1993 Richard Jakoby 1993-1997 Peter Becker 1997-2003 Klaus-Ernst Behne 2003-2005 Katja Schaefer 2006-2009 Rolf-Burkhard Klieme Since 2010 Susanne Rode-Breymann Bettina Wulff, media manager Official site Die Hochschule für Musik, Theater und Medien Hannover www.academics.de

Beta-1,3-N-acetylglucosaminyltransferase 3

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 is an enzyme that in humans is encoded by the B3GNT3 gene. This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family; this enzyme is a type II transmembrane protein and contains a signal anchor, not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a, it plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. B3GNT3 human gene location in the UCSC Genome Browser. B3GNT3 human gene details in the UCSC Genome Browser