Santiago Metropolitan Cathedral is the seat of the Archdiocese of Santiago de Chile and the main temple of the Catholic Church in that country. As a Cathedral Church, it is the permanent seat of the Archbishop of Santiago and is dedicated to the Assumption of the Virgin Mary.

Santiago, also known as Santiago de Chile, is the capital and largest city of Chile and one of the largest cities in the Americas. It is located in the country's central valley and is the center of the Santiago Metropolitan Region, which has a population of seven million, representing 40% of Chile's total population. Most of the city is situated between 500–650 m (1,640–2,133 ft) above sea level.