Santiago Metropolitan Region is one of Chile's 16 first-order administrative divisions. It is the country's only landlocked administrative region and contains the nation's capital, Santiago. Most commercial and administrative centers are located in the region, including Chile's main international airport, Arturo Merino Benítez International Airport.

Santiago, also known as Santiago de Chile, is the capital and largest city of Chile and one of the largest cities in the Americas. It is located in the country's central valley and is the center of the Santiago Metropolitan Region, which has a population of seven million, representing 40% of Chile's total population. Most of the city is situated between 500–650 m (1,640–2,133 ft) above sea level.