Santiago Papasquiaro is a municipality in the Mexican state of Durango. The municipal seat lies at Santiago Papasquiaro. The municipality covers an area of 7,238.4 km2. Santiago Papasquiaro municipality is at an average height of 1,730 m (5,675 ft) over the sea level. The municipality lies east of Sierra Madre Occidental Mountain Range. It neighbors with the municipalities of Canelas and Tepehuanes to the north, San Dimas and Otáez to the south, Nuevo Ideal to the east, Tamazula to the west and El Oro to the northeast.

Durango is a state in Northwest Mexico that is divided into 39 municipalities. According to the 2020 Mexican census, Durango is the 25th most populous state with 1,832,650 inhabitants, but the 4th largest by land area spanning 123,575.36 square kilometres (47,712.71 sq mi). Durango has a population density of 14.8/km2 (38.4/sq mi), making it Mexico's second-lowest dense state, after Baja California Sur.