Santiago de los Caballeros, often shortened to Santiago, is the second-largest city in the Dominican Republic and the fourth-largest city in the Caribbean by population. It is the capital of Santiago Province and the largest major metropolis in the Cibao region of the country. Santiago is the largest Caribbean city that is not a capital city, and it is also the largest non-coastal metropolis in the Caribbean islands. The city has a total population of 771,748 inhabitants (2022). Santiago is located approximately 155 km (96 mi) northwest of the capital Santo Domingo with an average altitude of 178 m (584 ft).

Santiago is a province which currently comprises one of the 32 provinces of the Dominican Republic. It is divided into 10 municipalities and its capital city is Santiago de los Caballeros. Located in north-central Dominican Republic, in the Cibao region, it is bordered by the provinces of Valverde to the north-west, Puerto Plata to the north, Espaillat and La Vega to the east, San Juan to the south and Santiago Rodríguez to the west.