Santiam Pass is a 4,817-foot (1,468 m) mountain pass in the Cascade Range in central Oregon in the United States. It is located on the border between Linn and Jefferson counties, about 18 mi (29 km) northwest of Sisters, between the prominent volcanic horns of Three Fingered Jack to the north and Mount Washington to the south. Several other smaller volcanoes, including cinder cones and tuyas, are found near the summit of the pass. U.S. Route 20 connects eastern Oregon with the valley of the Santiam River on the west via Santiam Pass. One of the 19 or 20 lakes by the name of Lost Lake is located beside the highway just west of Santiam Pass. The pass may be approached from the west by three distinct routes:Oregon Route 22, also known as the North Santiam Highway, proceeds southeast from Salem and follows the North Santiam River to Santiam Junction. U.S. Route 20, which follows the South Santiam River from the Albany–Corvallis area to Santiam Junction. Oregon Route 126, which follows the McKenzie River northeast from Eugene.

Sisters is a city in Deschutes County, Oregon, United States. It is part of the Bend, Oregon Metropolitan Statistical Area. The population was 2,038 at the 2010 census.