Santo Domingo de la Calzada is a municipality in La Rioja, Spain, situated on the banks of the Oja River. Its name refers to its founder, Dominic de la Calzada, who built a bridge, hospital, and hotel here for pilgrims on the French Way the most popular path of the Way of St. James. He began construction of the town's Cathedral of Santo Domingo de la Calzada is buried within and it is dedicated to him.

La Rioja is an autonomous community and province in Spain, in the north of the Iberian Peninsula. Its capital is Logroño. Other cities and towns in the province include Calahorra, Arnedo, Alfaro, Haro, Santo Domingo de la Calzada, and Nájera. It has an estimated population of 315,675 inhabitants, making it the least populated autonomous community of Spain.