Santo International Airport is an airport in Luganville on Espiritu Santo in Vanuatu. The airport used to be called Santo-Pekoa International airport until it was renamed in the Vanuatu AIPV amendment released on 16 June 2021. Airports Vanuatu Limited provides aviation services for the airport.

Luganville is the second largest city in Vanuatu after the capital Port Vila; it is located on the island of Espiritu Santo and has a population of 18,062 as of the 2020 census. Those on Vanuatu's northern islands who regard Luganville as their big city, particularly indigenous populations, call it Santo; rural residents of Espiritu Santo call it Kanal. Luganville served as a major base of operations for American troops during World War II.