Santo vs. las Mujeres Vampiro is a 1962 superhero film starring the wrestling superhero Santo. The film was featured on a 1995 episode of Mystery Science Theater 3000.

Rodolfo Guzmán Huerta, best known by his ring name El Santo, was a Mexican luchador enmascarado, actor and folk hero. He is one of the most famous and iconic Mexican luchadores, and has been referred to as one of "the greatest legends in Mexican sports". His wrestling career spanned nearly five decades, during which he became a folk hero and a symbol of justice for the common man through his appearances in luchador films and comic books telling fictionalized stories of El Santo fighting for justice. He starred or co-starred in at least 54 movies between 1958 and 1982.