The Sassanid campaign of Alexander Severus was an episode of the Roman–Sasanian Wars (224-363) that saw the Roman Empire ruled by Emperor Alexander Severus (222-235) confront the dominance of the Sasanids, led by Ardashir I (224-241): the war was fought between 230 and 232, originating from an attempted Sasanian expansion into the eastern Roman provinces, and resolved with a return to the status quo ante.

Marcus Aurelius Severus Alexander, also known as Alexander Severus, was Roman emperor from 222 until 235. The last emperor from the Severan dynasty, he succeeded his slain cousin Elagabalus in 222, at the age of 13. Alexander himself was eventually assassinated, and his death marked the beginning of the events of the Crisis of the Third Century, which included nearly fifty years of civil war, foreign invasion, and the collapse of the monetary economy.