The Sassetti Chapel is a chapel in the basilica of Santa Trinita in Florence, Italy. It is especially notable for its frescoes of the Stories of St. Francis, considered Domenico Ghirlandaio's masterwork.

Santa Trinita is a Roman Catholic church located in front of the piazza of the same name, traversed by Via de' Tornabuoni, in central Florence, Tuscany, Italy. It is the mother church of the Vallumbrosan Order of Monks, founded in 1092 by a Florentine nobleman. South on Via de' Tornabuoni is the Ponte Santa Trinita over the river Arno; across the street is the Palazzo Spini Feroni.