Sauganash Hotel is a former hotel; regarded as the first hotel in Chicago, Illinois. Built in 1831, it was located at Wolf Point in the present day Loop community area at the intersection of the north, south and main branches of the Chicago River. The location at West Lake Street and North Wacker Drive was designated a Chicago Landmark on November 6, 2002. The hotel changed proprietors often in its twenty-year existence and briefly served as Chicago's first theater. It was named after Sauganash, an interpreter in the British Indian Department.

Wolf Point is the location at the confluence of the North, South and Main Branches of the Chicago River in the present day Near North Side, Loop, and Near West Side community areas of Chicago. This fork in the river is historically important in the development of early Chicago. Located about 1.6 miles (2.6 km) from Lake Michigan, this was the location of Chicago's first three taverns, its first hotel, Sauganash Hotel, its first ferry, its first drug store, its first church, its first theater company, and the first bridges across the Chicago River. The name is said to possibly derive from a Native American Chief whose name translated to wolf, but alternate theories exist.