Saulsbury is a town in rural Hardeman County, Tennessee. It is located along State Highway 57 in southwest Hardeman County. The population was 99 at the 2000 census and 81 at the 2010 census showing a decrease of 18. Saulsbury is the least-populated incorporated municipality in Tennessee.

Hardeman County is a county located in the U.S. state of Tennessee. As of the 2020 census, the population was 25,462. Its county seat is Bolivar.