The Saxon Lutheran immigration of 1838–39 was a migration of Confessional German Lutherans seeking religious freedom in the United States in the early 19th century. The immigrants were among the original founders of the Lutheran Church – Missouri Synod.

The Lutheran Church – Missouri Synod (LCMS), also known as the Missouri Synod, is an orthodox, traditional, confessional Lutheran denomination in the United States. With 1.8 million members as of 2021, it is the second-largest Lutheran body in the United States, behind the Evangelical Lutheran Church in America. The LCMS was organized in 1847 at a meeting in Chicago, Illinois, as the German Evangelical Lutheran Synod of Missouri, Ohio, and Other States, a name which partially reflected the geographic locations of the founding congregations.