The Sayre Fire, also known as the Sylmar Fire, was a November 2008 wildfire that resulted in the loss of 489 residences in Los Angeles, California, United States, the "worst loss of homes due to fire" in the city's history. The fire was first reported at 10:29 p.m. PDT on November 14, 2008, in the Sylmar section of Los Angeles. As of November 20, 2008, the fire was 100% contained, had burned 11,262 acres (46 km2) and destroyed more than 600 structures. The number of homes lost in the Sayre fire exceeded the prior record set in 1961 by the Bel Air Fire which claimed 484 homes. There were no fatalities, just minor injuries to five firefighters and one civilian.

Sylmar is a suburban neighborhood in the San Fernando Valley and is the northernmost neighborhood within the city of Los Angeles. Historically known for its profusion of sylvan olive orchards, Sylmar can trace its past to the 18th century and the founding of the San Fernando Mission. In 1890, olive production was begun systematically. The Sylmar climate was also considered healthy, and so a sanitarium was established, the first in a series of hospitals in the neighborhood. There are fourteen public and eight private schools within Sylmar.