A Palestinian suicide bombing at a pizzeria in downtown Jerusalem on 9 August 2001 killed 16 people, including seven children and a pregnant woman. A further 130 were wounded. The attack occurred during the Second Intifada.

The Second Intifada, also known as the Al-Aqsa Intifada, was a major uprising by Palestinians against the Israeli occupation, characterized by a period of heightened violence in the Palestinian territories and Israel between 2000 and 2005. The general triggers for the unrest are speculated to have been centered on the failure of the 2000 Camp David Summit, which was expected to reach a final agreement on the Israeli–Palestinian peace process in July 2000. An uptick in violent incidents started in September 2000, after Israeli politician Ariel Sharon made a provocative visit to the Al-Aqsa compound, which is situated atop the Temple Mount in East Jerusalem; the visit itself was peaceful, but, as anticipated, sparked protests and riots that Israeli police put down with rubber bullets, live ammunition, and tear gas. Within the first few days of the uprising, the IDF had fired one million rounds of ammunition.