Schleitheim is a municipality in the canton of Schaffhausen in Switzerland, located directly on the border with Germany.

The canton of Schaffhausen, also canton of Schaffhouse, is the northernmost canton of Switzerland. The principal city and capital of the canton is Schaffhausen. The canton's territory is divided into three non-contiguous segments, where German territory reaches the Rhine. The large central part, which includes the capital, in turn separates the German exclave of Büsingen am Hochrhein from the rest of Germany.