The School of Medical Sciences at the University of Manchester is one of the largest in the United Kingdom with around 6,000 undergraduates, 3,000 postgraduates and 2,000 staff. It is the third oldest medical school in England and the largest medical school in the United Kingdom. The Faculty is a member of the Manchester Academic Health Science Centre and has four affiliated teaching hospitals at Manchester Royal Infirmary, Wythenshawe Hospital, Salford Royal Hospital and the Royal Preston Hospital.

Manchester Royal Infirmary (MRI) is a large NHS teaching hospital in Chorlton-on-Medlock, Manchester, England. Founded by Charles White in 1752 as part of the voluntary hospital movement of the 18th century, it is now a major regional and national medical centre. It is the largest hospital within Manchester University NHS Foundation Trust, and based on its Oxford Road Campus in South Manchester where it shares a site with the Royal Manchester Children's Hospital, Manchester Royal Eye Hospital and Saint Mary's Hospital as well as several other educational and research facilities. The Hospital is also a key site for medical educational within Manchester, serving as a main teaching hospital for School of Medical Sciences, University of Manchester.