Science House is a heritage-listed commercial building located at 157–169 Gloucester Street and Essex Street, in the inner city Sydney suburb of The Rocks in the City of Sydney local government area of New South Wales, Australia. It was designed by Peddle Thorp & Walker Architects and built in 1930 by John Grant and Sons, Master Builders. It was also known as Sports House from 1978–1991. The building is owned by Denwol, a property group owned and controlled by Phillip Wolanski AM. It was added to the New South Wales State Heritage Register on 10 May 2002.

The Rocks is a suburb, tourist precinct and historic area of Sydney's city centre, in the state of New South Wales, Australia. It is located on the southern shore of Sydney Harbour, immediately north-west of the Sydney central business district.