Science and Health with Key to the Scriptures by Mary Baker Eddy is, along with the Bible, one of the two central texts of the Christian Science religion. Eddy described it as her "most important work". She began writing it in February 1872, and the first edition was published in 1875. However, she would continue working on it and making changes for the rest of her life.

Mary Baker Eddy was an American religious leader and author who founded The Church of Christ, Scientist, in New England in 1879. She also founded The Christian Science Monitor in 1908, and three religious magazines: the Christian Science Sentinel, The Christian Science Journal, and The Herald of Christian Science. She wrote numerous books and articles, the notable of which were Science and Health with Key to the Scriptures and Manual of The Mother Church. Other works were edited posthumously into the Prose Works Other than Science and Health.