Scooba is a town in Kemper County, Mississippi, United States. The population was 744 as of the 2020 Census.

Mississippi Highway 16 is a state highway in central Mississippi. It runs east–west for 186.4 miles (300.0 km), from the Mississippi Delta region to the Alabama state line. MS 16 serves 8 counties: Issaquena, Sharkey, Yazoo, Humphreys, Madison, Leake, Neshoba, and Kemper.