Scotland County is a county in northeastern Missouri. As of the 2020 census, its population was 4,716, making it Missouri's seventh-least populous county. Its county seat is Memphis. The county was organized on January 29, 1841, and named for the country of Scotland.

Knox County is a county located in the northeast portion of the U.S. state of Missouri. As of the 2020 census, its population was 3,744, making it the third-least populous county in Missouri. Its county seat is Edina. The county was organized February 14, 1845, and named for U.S. Secretary of War General Henry Knox.