The fifth and final season of the American television series Señora Acero also known as Señora Acero: La Coyote, follows the life of Vicenta Acero, 6 years after the death of her husband Daniel Philips and her new future as a mother. The season was ordered in February 2018, with filming beginning that August. It was later announced that the fifth season would be the final season. Principal cast members Carolina Miranda, Ana Lucía Domínguez, and Diego Cadavid return from previous seasons. The season premiered on 15 October 2018, and concluded on 29 January 2019.

Señora Acero, also known as Señora Acero: La Coyote as of season three, is an American telenovela created by Roberto Stopello and produced by Argos Comunicación and Telemundo Studios, and distributed by Telemundo Internacional. The series debuted on American broadcast channel Telemundo on 23 September 2014, and concluded on 29 January 2019.