Señorita Panamá 2006 the 24th Annual Señorita Panamá pageant and 41st celebration of the Miss Panama contest, was held in the Gran Salón del Hotel & Casino Venetto, Panama City, Panama Wednesday 15, July 2006.

The Señorita Panamá is a national beauty pageant in Panama. As of the 2024 edition, Señorita Panamá winners represent Panamá in Miss Universe and Miss International. The Miss Panama brand started in 1952, when the Panamanian Institute of Tourism received an invitation from Miss Universe to send a representative. In 1975, the Señorita Panamá name was used for the first time, reverting to Miss Panama in 1976. In 1982, Señorita Panamá was created by RPC Channel 4 as an alternative to send its winners to the Miss World contest in London. These pageants, along with smaller pageants such as Miss International Panamá and Miss World Panamá celebrated to select delegates for international representations.