Señorita Panamá 2019 was the 53rd Señorita Panamá pageant. It selected the national representatives to the Miss Universe, Miss International, and Miss Grand International competitions. This was the fourth edition of the renewed Señorita Panama pageant, under the direction of Cesar Anel Rodríguez, who took charge of the national event in 2016. Twenty-four preliminary contestants were selected from throughout Panama and competed for the crown.

The Señorita Panamá is a national beauty pageant in Panama. As of the 2024 edition, Señorita Panamá winners represent Panamá in Miss Universe and Miss International. The Miss Panama brand started in 1952, when the Panamanian Institute of Tourism received an invitation from Miss Universe to send a representative. In 1975, the Señorita Panamá name was used for the first time, reverting to Miss Panama in 1976. In 1982, Señorita Panamá was created by RPC Channel 4 as an alternative to send its winners to the Miss World contest in London. These pageants, along with smaller pageants such as Miss International Panamá and Miss World Panamá celebrated to select delegates for international representations.